Professor Dweeb maintained his base of operations from his mother's basement, converted into a laboratory. Mrs. Dweeb mainly occupied the second floor and watched television.
The Real Ghostbusters
After Dweeb posed as an ice cream vendor and kidnapped Slimer, he brought the spud to his home laboratory. Dweeb began going through Slimer's memories to accumulate data on ghost's weaknesses but Slimer figured how to overload it. As a result, the house blew up and was left in ruins.
- "Deja Boo"