It was also the first known place where Psychomagnotheric Slime came to the surface and the first known place it tried to kidnap Oscar. It made contact with Dana's baby carriage wheels and attempted to steer the carriage, with Oscar inside, away but stopped before a bus crashed into it. After Dana enlisted Egon's help, he, Ray, and Peter ran a sweep on First Avenue. Egon and Ray got their first readings on the Mood slime and decided to dig a hole in First Avenue. Under the guise of Con Edison, the team began construction. Although, it appeared only Egon made the hole with the use of a jack hammer while Ray and Peter went to get coffee, for an hour.
Ray was volunteered to go down into hole. He discovered the abandoned Van Horne Pneumatic Transit Station was directly under First Avenue and it was filled with a river of slime. He took a sample with the Slime Scooper but the river began to attack him. Eventually, the police confronted them and verified their lie with Mr. Fianella, from Con Edison. As Ray was pulled up in a panic, he knocked out several lines and caused a power outage. The Ghostbusters were arrested soon after. After they went back into business, they turned onto East 76th Street from First Avenue one night.
- In the Ghostbusters II August 5, 1988 draft, the incident with the baby carriage chase takes place on Sixth Avenue instead of First Avenue. 
- The baby carriage chase at the start of the movie is geographically accurate. It starts at Dana's apartment building at 325 East 77th Street and heads south to the intersection of East 77th Street and First Avenue where it stopped. After the carriage is nearly hit by the bus, the green awning of Cho-Sen Food Shoppe Ltd. is visible, further proving the intersection is E. 77th and First. 
- Chuck Gaspar, physical effects supervisor, built five radio-controlled carriages for the baby carriage chase. DC motors were placed in the buggy baskets, drive shafts, a steering system, and two braking systems to stop the wheels and slow the carriage were utilized. Gaspar brought in two-time national champion driver of miniature cars Jay Halsey, both having worked on Dirty Harry movies, to steer the carriage. 
- Two blocks from the intersection of East 77th and First, Louis' bus stop scene was filmed.
- The digging scenes on First Avenue were filmed on a similar street in Los Angeles.
- Filming the digging scene did not go well. Generator fuses blew, the crew got cranky, and Ivan Reitman thought the pacing was ruined by the police car driving away too slowly.
- The part where Ray realizes he was voted to go down the hole took at least 8 takes.
- For the first montage a night shot of Ecto-1a was filmed at the corner of East 76th Street and First Avenue, evidenced by 3-Star Diner, located at 1463 First Avenue.
- Ghostbusters II
- The Prosecutor (1999). Ghostbusters II, Chapter 10: Their Day in Court (1989) (DVD ts. 30:38-30:52). Columbia Pictures. The Prosecutor says: "Dr. Venkman, would you please tell the court why it is that you and your co-defendants took it upon yourselves to dig a very big hole in the middle of First Avenue?"
- Aykroyd, Dan & Ramis, Harold (1988). Ghostbusters II (August 5, 1988 Draft) (Script p. 14). "Paragraph reads: "Cars, trucks, and buses speed by on Sixth Avenue as the buggy races toward the corner."
- Spook Central, Dana's apartment
- Eisenberg, Adam (November 1989). Ghostbusters Revisited, Cinefex magazine #40, page 6. Cinefex, USA.
- Goldstein, Patrick (June 1, 1989). "Return of the Money Making Slime" Rolling Stone #553, page 54. Wenner Media LLC, New York City, New York, USA. Line reads: "This is still L.A., downtown L.A. to be exact, normally a deserted isle, especially on a drizzly, cold spring night. Two blocks away, you can find a platoon of skid-row bums huddled under cardboard boxes, sharing sips of wine. On the set, several hundred extras are milling around a "crowded Manhattan intersection." Posing as Con Ed repairmen, the Ghostbusters are on the hunt for slime. Ramis is jackhammering a hole in the middle of the street. Just when it looks like he's hit pay dirt, a patrol car stops to investigate. The scene is not going well. Generator fuses are blowing out. The crew is cranky. Murray is yawning. It's no wonder Reitman is wearing a groove in the sidewalk behind his camera position. When you're rushing to finish a $30 million movie, time is money, the meter is running. He quickly decides what is ruining the pacing. The cop car isn't leaving the scene fast enough. "That is the slowest cop car I've ever seen," Reitman growls."
- Goldstein, Patrick (June 1, 1989). "Return of the Money Making Slime" Rolling Stone #553, page 54. Wenner Media LLC, New York City, New York, USA. Line reads: "The night's scene concludes with the three staring down the manhole, then at one another - no one is volunteering to slide down into the slime-filled sewer. On the eighth take, they're completely in sync - they move as if attached to one another with imaginary puppet strings. Who'll hit the sewers tonight? Ramis looks at Murray. Murray eyes Ramis. Then they both slowly swivel their heads. staring at Aykroyd. He rolls his eyes skyward, praying for divine intervention. His woeful gaze is painfully funny."
- Spook Central First Avenue page
- Winston Zeddemore (2017). IDW Comics- "Ghostbusters Annual 2017" (2017) (Comic p.8). Winston Zeddemore says: "Some of us had the good sense to not get arrested for digging up a street in the middle of NYC."