The H2 Ghost is a ghost that can split off into two separate forms.
The H2 Ghost manifested on Lexington Avenue and grabbed the left leg of a businesswoman who stepped on it. Naturally, she screamed. Ray Stantz blasted both the woman and ghost with positively charged Psychomagnotheric Slime from his Slime Blower to prevent a forced possession. The other half hissed then recombined. The ghost attempted to fly away but it was wrangled in a Proton Stream by Peter Venkman. Winston Zeddemore threw out a Trap and captured it.
- The ghost is visually based on Kenner's H2 Ghost.
- Dan Schoening waited about 5 years to draw H2 Ghost in the comic books. 
- On page five of Ghostbusters Volume 1 Issue #6, several H2 Ghost dolls can be see in the Fantastic Land stand. They are later among the Possessed Stuffed Dolls that attack Peter and Ray.
- On page two of Teenage Mutant Ninja Turtles/Ghostbusters Volume 2 Issue #1, in panel 3, the H2 Ghost is now in its combined form.